Healthcare providers and individuals using Arterosil HP often ask how to track if it is working. Answering the question of whether or not Arterosil HP is working is best done by measuring vascular health holistically. 

At a Glance, 4 ways to monitor if Arterosil HP is supportive:*

1. Self-reported vascular wellness 
   1. Temperature in fingers and toes
   2. Sexual wellness
   3. Focus and cognitive function
2. At-home or in-clinic measurement of blood pressure and nitric oxide
3. Functional vascular assessments like carotid-intima media thickness (CIMT), pulse wave velocity, and heart rate variability
4. Cardiometabolic lab markers like fasting glucose and Cardio IQ

Arterosil HP specifically supports the endothelial glycocalyx (EGX), the fragile, gel-like lining of every blood vessel in your body.* Because we cannot directly feel our vascular health, the signs that it’s working aren’t typically felt either. This article walks through four categories of vascular health markers to help answer the question, how do I know Arterosil HP is working? These categories include what individuals can feel and what clinicians can track.

What You’re Actually Tracking, and Why It Matters

The vascular system is critically important for human health.* In fact, vascular issues are the greatest barrier to longevity for most people. Unfortunately, most people do not notice their vascular system until something scary happens. This is why it is so critical to support vascular health, even if you cannot feel it.

Arterosil HP with Monitum RS® directly supports the endothelial glycocalyx (EGX).* The endothelial glycocalyx (EGX) is one of the most critical aspects of overall vascular health.* The EGX lines all 60,000 miles of blood vessels in the human body. When it’s intact and functioning well, it supports healthy circulation, helps maintain normal vascular tone, and helps every organ and system receive the oxygen and nutrients it needs to function properly.* When the endothelial glycocalyx is supported, vascular function is also supported, often quietly and without being obviously felt.*

Arterosil HP with MonitumRS is the gold standard for endothelial glycocalyx support.* In vitro, MonitumRS has been scientifically shown to protect and restore the endothelial glycocalyx up to 103.8% of baseline in just 24 hours.*† 

This research was done with living human endothelial glycocalyx cells. At this time, directly measuring the health of the endothelial glycocalyx throughout the human body isn’t yet possible.

Here’s the key insight for monitoring: you don’t need to be able to measure the endothelial glycocalyx (EGX) directly to know that it’s being supported. Because the EGX is so foundational for vascular health, improvements in its structure tend to show up across a wide range of vascular markers. Any vascular measure that moves in a positive direction — subjective or objective — can serve as a meaningful proxy for the benefits of a vascular wellness plan that includes Arterosil HP.*

That’s what makes tracking both practical and motivating. What follows is a five-category framework to track overall vascular health, which serves as the best proxy regularly available for tracking endothelial glycocalyx health.*

Self-Reported Vascular Wellness: What Individuals Can Feel

When carefully tracked, some individuals notice quality-of-life shifts that reflect changing vascular function. These changes tend to be gradual, which means they’re easy to miss without a documented baseline to compare against. People adapt to feeling better remarkably fast, which is a good reason to document the starting point carefully.

The Calroy Vascular Health Tracker is a structured checklist designed for weekly vascular wellness monitoring. Use it at baseline and then weekly to help identify subtle shifts in vascular health and function.*

Energy and stamina during activity*

One of the most commonly reported early shifts in vascular function is a change in physical stamina, including sustaining effort longer before fatigue sets in, recovering more quickly after activity, or finding that the same daily tasks simply feel less effortful. This maps directly to vascular function: endothelial-dependent circulation governs oxygen delivery to working tissue.*

Peripheral circulation comfort*

Cold hands and feet or tingling or numbness in the extremities are among the subtler but consistent signals of microvascular status. Individuals who note cold or tingly fingers or toes at baseline often report meaningful shifts in comfort when tracking consistently.*

Cognitive clarity and mental energy*

The brain is highly sensitive to microvascular function. Brain fog, difficulty sustaining focus, or low mental energy in the afternoon are connected to microvascular health in the brain. Clinicians working with individuals on vascular wellness plans often cite cognitive sharpness as one of the reported changes.* 

It is also important to note that the importance of endothelial glycocalyx health on brain health is becoming more known in the research.

Sexual wellness*

Sexual health and wellness are directly connected to healthy vascular health and microcirculation. Changes in sexual health are great indicators of shifts in vascular health and can be easily identifiable markers of changes in vascular health status.*

Clinician Note: Baseline scoring is critical for compliance, and checklists like this are a very simple way to start. Without a documented starting point, even significant progress can go unrecognized as individuals adapt to their new normal.

Simple Measurements: Blood Pressure & Salivary NO

Blood pressure and salivary NO are two of the most accessible objective vascular health markers, as they can both be taken easily in any healthcare provider’s clinic or even in a home setting. 

The endothelial glycocalyx (EGX) plays a direct role in vascular tone and healthy blood pressure in the normal range.* It transmits shear stress signals from blood flow to the endothelium, which in turn influences how blood vessels respond dynamically to changing conditions. As EGX integrity is supported, that regulation becomes more precise.*

What to track:

• Resting systolic and diastolic readings — both in office and at home
• Nitric oxide using salivary test strips

More Advanced Measurements: Functional Vascular Assessments

For clinicians with access to vascular assessment tools, this category offers some of the most direct windows into endothelial glycocalyx function available outside of research settings.

Carotid intima-media thickness (CIMT)

CIMT imaging provides a structural look at vascular wall integrity over time. Changes here occur over months and years, making it better suited to baseline and then 6- and 12-month reassessments. The CIMT can be a very powerful and engaging tool because it also provides clinicians and individuals with a calculated “vascular age” compared to peers that is independent of chronological age, and individuals can work to lower through vascular wellness plans. 

Dr. Kristine Burke, MD, and Calroy Board Member published a case series where she used CIMT measurement to track 6 individuals using Arterosil HP for 6 months. The results speak for themselves.

Clinician notes: Healthcare providers can login to Calroy’s practitioner education hub to find a Clinical Grand Rounds session with Brian Hiller, where he used CIMT to track vascular health with individuals in his clinic. 

Pulse wave velocity (PWV)

Pulse wave velocity is a validated marker of vascular aging. As the EGX supports healthier endothelial signaling over time, arteries tend to become more compliant and flexible as the EGX becomes healthier.* Baselines and 3–6 month follow-up PWV measurements provide compelling objective data of overall vascular health.

Endothelial function testing

Flow-mediated dilation (FMD) directly measures endothelium-dependent vasodilation — one of the clearest functional proxies for vascular and therefore EGX health. For practices already running this testing, these are among the most meaningful markers to track alongside an Arterosil HP regimen.

Blood Biomarkers: Cardiometabolic Lab Panels

No standard blood biomarker directly measures the health of the endothelial glycocalyx, but several cardiometabolic markers are appropriate to track as part of a structured vascular wellness plan, and point to endothelial glycocalyx health.

CBC with differential

A complete blood count with differential is a simple and commonly ordered test that provides a broad baseline snapshot of overall physiological status and is a practical addition to any vascular wellness panel. While it doesn’t measure EGX function directly, it adds useful context for the overall health of the vascular system, and especially microvascular health.

Fasting glucose and insulin

Metabolic dysregulation is one of the most well-documented accelerators of EGX thinning. Spikes in blood sugar erode the endothelial glycocalyx, as documented in many studies. Since the endothelial glycocalyx protects the endothelium, its erosion opens up the endothelium to stressors. Tracking fasting glucose and insulin captures a key upstream driver for vascular health. Glycemic control and monitoring blood sugar is key to any wellness plan with a vascular focus.

General Cardiovascular Panels

In-depth assessment panel including CBC, CMP, and a  lipid panel (Dr. Monique Class, APRN-BC, IFMCP, NBC-HWC, AHNCC suggests the Cardio IQ® testing from Quest Diagnostics)

Free clinical program and tools: Healthcare providers getting started with advanced vascular wellness plans – Calroy has tools for you. You can access a 12-page, clinician-authored protocol that outlines these and many other assessments, as well as target ranges as part of the completely free vascular health program available from Calroy Health Sciences. The full program, including the protocol, many other resources, and 1:1 implementation support are available free of charge to healthcare providers.

For Clinicians: Building a Full Vascular Program in Your Practice

Tracking vascular health and Arterosil HP’s effects is most powerful when it’s part of a structured vascular wellness program with consistent assessments, personalized recommendations, and clear follow-up milestones.

Calroy’s Vitality in Motion program gives licensed healthcare professionals everything needed to run a full vascular health program, at zero cost. It includes a 12-page clinician-authored protocol, baseline and follow-up assessment tools, editable patient education materials, and 1:1 implementation support. It is completely free, from start to finish.

Clinicians who use Vitality in Motion report that having a consistent structure — from education to enrollment to outcomes tracking — transforms vascular health from a one-time conversation into an ongoing, measurable program that individuals stay engaged with long-term.

Learn more about Vitality in Motion and schedule a complimentary implementation call with the Calroy team.

Frequently Asked Questions

How soon will Arterosil HP start to work?

Some individuals notice subjective shifts particularly in energy, cognitive clarity, and peripheral circulation comfort within weeks or days. Generally, we cannot feel the health of our vascular system the same way we can other systems, it can be hard to notice a difference. Documenting a baseline with the Vascular Health Tracker helps track progress over time. Other measurements like blood pressure readings can help track vascular health over time.*

How long before evaluating whether Arterosil HP is working?

In a published case series, Calroy Board Member Dr. Kristine Burke saw meaningful changes after 6 months of using Arterosil HP. She used the CIMT assessment as the main monitoring tool in the series. Some more basic assessments, like self-report tools or lab panels can be reassessed earlier, at 90 or 120 days.

Is there a direct way to measure the health of the endothelial glycocalyx?

At this time, there is no easily accessible, validated, in-clinic or at-home measurement that can assess system-wide endothelial glycocalyx health. Instead, measurements of overall vascular function are indicative of endothelial glycocalyx health, because you cannot have a healthy vascular system without a healthy endothelial glycocalyx. Therefore, any vascular changes indicate endothelial glycocalyx changes.*

Is there a checklist for tracking vascular health?

Yes. One option is the Calroy Vascular Health Tracker. This is a simple assessment tool covering energy, peripheral circulation, cognitive function, and sexual health. There are also more robust and standardized tools that can be used in a clinical setting.

How does Arterosil HP fit into a broader vascular wellness program?

Tracking Arterosil HP outcomes is most effective as part of a complete vascular wellness plan that includes diet, movement, and structured clinical monitoring. Calroy’s Vitality in Motion program provides licensed healthcare professionals with a free, turnkey framework, including assessment tools, clinician protocols, individual education materials, and live implementation support to build a vascular program in their practice.